tert-butyl trans-3-(hydroxymethyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-1-carboxylate - Names and Identifiers
tert-butyl trans-3-(hydroxymethyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-1-carboxylate - Introduction
tert-butyl trans-3-(hydroxymethyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-1-carboxylate is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless or light yellow oily liquid
-molecular formula: C15H19F3NO3
-Molecular weight: 325.31g/mol
-Melting Point: No clear melting point recorded
-Boiling Point: No clear boiling point recorded
-Solubility: Soluble in organic solvents such as ether and alcohol
Use:
tert-butyl trans-3-(hydroxymethyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-1-carboxylate is commonly used as a reagent in organic synthesis for the synthesis of other compounds. It has important application value in the fields of drug research and development, medicinal chemistry and chemical research.
Method:
The tert-butyl trans-3-(hydroxymethyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-1-carboxylate can be synthesized by reaction steps:
1. Reaction of N-tert-butoxycarbonyl pyrrolidine with 3-(trifluoromethyl) benzaldehyde to give the corresponding N-tert-butoxycarbonyl pyrrolidone compound.
2. Under alkaline conditions, the ketone compound is reacted with a hydroxymethylating reagent to generate a tert-butyl trans-3-(hydroxymethyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-1-carboxylate.
Safety Information:
tert-butyl trans-3-(hydroxymethyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-1-carboxylate is safe under normal use conditions, the following safety operations still need to be followed:
-Avoid contact with skin, eyes and mucous membranes. Wear personal protective equipment such as gloves and goggles when using.
-Operate in a well-ventilated place to avoid inhaling its vapors.
-Keep it tightly closed during storage, away from open flames and high temperatures.
Please note that this article only provides a basic introduction to this compound and does not replace professional chemical experiments and safety knowledge. When using this compound, please follow the relevant laws and regulations and laboratory instructions. If necessary, please consult chemical professionals or relevant institutions for guidance and advice.
Last Update：2024-04-09 15:18:04